65 Vitamins and Supplements for Menopause Relief

Menopause can bring a range of physical, mental, and emotional changes as hormone levels shift. During this time, certain vitamins and supplements can help ease symptoms, restore balance, and improve overall well-being. Below is a comprehensive and informative guide to 65 vitamins, minerals, and supplements that may help support women going through perimenopause, menopause, or post menopause. Each entry includes details on its role, benefits, and suggested applications for menopause support.


1. Vitamin D – Vital for calcium absorption and maintaining bone density, which helps prevent osteoporosis. It also regulates mood and supports immune health, making it especially crucial during hormonal shifts.

2. Calcium – As estrogen levels decline, calcium helps maintain bone mass, reducing the risk of fractures and bone loss. It is best absorbed when paired with Vitamin D and Vitamin K2.

3. Magnesium – Helps reduce hot flashes, promotes restful sleep, calms the nervous system, and supports heart health. It also aids in muscle relaxation and energy production.

4. Vitamin B6 (Pyridoxine) – Supports the production of serotonin and dopamine, which can help reduce mood swings, irritability, and depression commonly experienced during menopause.

5. Vitamin B12 (Cobalamin) – Essential for brain function, memory, and energy levels. Helps reduce brain fog and supports nerve health.

6. Folate (Vitamin B9) – Crucial for mood stability, DNA repair, and red blood cell formation. May help reduce symptoms of depression and cognitive decline.

7. Vitamin E – Acts as an antioxidant, reducing oxidative stress and easing hot flashes and night sweats. It also supports skin health and elasticity.

8. Omega-3 Fatty Acids – Found in fish oil, they reduce inflammation, support cardiovascular and cognitive health, and may help with mood stabilization.

9. Zinc – Supports immune function, promotes healing, and plays a role in skin and hair health. It also contributes to hormone balance.

10. Selenium – A powerful antioxidant that supports thyroid function and protects against cellular damage. It may reduce mood swings and fatigue.

11. Iron – Necessary for oxygen transport in the blood. Important during perimenopause for women who still experience menstruation.

12. Iodine – Crucial for thyroid hormone production, which can affect energy levels, metabolism, and temperature regulation.

13. Vitamin C – Strengthens immune function, enhances iron absorption, and supports collagen production, which benefits skin, joints, and blood vessels.

14. Biotin – Promotes strong hair, skin, and nails, often compromised due to hormonal changes.

15. Collagen – Supports skin elasticity, joint function, and bone density. Collagen production naturally declines with age.

16. Vitamin K1 – Plays a key role in blood clotting and bone metabolism. Helps direct calcium to the bones and prevent arterial calcification.

17. Vitamin K2 – Works in synergy with Vitamin D to ensure calcium is deposited in bones, not soft tissues. Critical for preventing osteoporosis and heart disease.

18. Black Cohosh – Herb known to reduce hot flashes, night sweats, and mood disturbances by modulating estrogen receptors.

19. Dong Quai – Traditional Chinese herb that may help balance hormones and alleviate menstrual-like symptoms in perimenopausal women.

20. Maca Root – Adaptogenic root that supports hormonal balance, improves mood, boosts libido, and enhances energy.

21. Ashwagandha – A well-known adaptogen that lowers cortisol, reduces anxiety, improves sleep quality, and supports adrenal health.

22. Rhodiola Rosea – Enhances resilience to physical and emotional stress, reduces fatigue, and improves mental clarity.

23. Evening Primrose Oil – Contains GLA which may ease breast tenderness, support hormone balance, and reduce inflammation.

24. Chasteberry (Vitex) – Helps regulate the pituitary gland, supporting balanced progesterone levels and easing PMS-like symptoms.

25. L-Theanine – An amino acid that promotes relaxation and reduces anxiety without drowsiness. Supports restful sleep.

26. GABA (Gamma-Aminobutyric Acid) – A calming neurotransmitter that helps with anxiety, tension, and sleep disturbances.

27. Probiotics – Promote gut health, which influences hormone regulation, immune function, and mental health.

28. CoQ10 – Antioxidant that supports cellular energy production and cardiovascular health.

29. Alpha-Lipoic Acid (ALA) – Regenerates other antioxidants, supports metabolic function, and protects against nerve damage.

30. Turmeric (Curcumin) – Anti-inflammatory compound that may help relieve joint pain, reduce depression, and enhance brain function.

31. Resveratrol – A polyphenol that mimics estrogen’s effects, supports cardiovascular health, and reduces inflammation.

32. Soy Isoflavones – Plant estrogens that may reduce hot flashes and improve bone health by mimicking mild estrogenic effects.

33. Flaxseed – Contains lignans and omega-3s, promoting estrogen balance and relieving hot flashes.

34. Red Clover – Rich in phytoestrogens, helps maintain cardiovascular health and bone density.

35. Licorice Root – Adaptogen that supports adrenal function and may help balance cortisol and estrogen levels.

36. Schisandra Berry – Traditional Chinese herb that helps with liver detoxification, energy, and hormonal balance.

37. Ginseng – Increases vitality, reduces fatigue, and improves mental performance and libido.

38. Melatonin – A natural hormone that supports circadian rhythm regulation, especially helpful for insomnia linked to menopause.

39. L-Tryptophan – Amino acid that promotes serotonin production, improving mood and promoting sleep.

40. 5-HTP (5-Hydroxytryptophan) – Converts into serotonin, helping alleviate mood swings, anxiety, and sleep issues.

41. Hops Extract – Contains phytoestrogens that may reduce hot flashes and promote restful sleep.

42. Valerian Root – Natural sedative that improves sleep quality and reduces nighttime awakenings.

43. Boron – Enhances the metabolism of estrogen, magnesium, and calcium; helps prevent bone loss.

44. Chromium – Stabilizes blood sugar levels, which can affect energy, mood, and weight gain in menopause.

45. L-Glutamine – Amino acid that strengthens gut lining, supports immune function, and reduces sugar cravings.

46. MSM (Methylsulfonylmethane) – Supports joint comfort, skin elasticity, and inflammation reduction.

47. Hyaluronic Acid – Helps retain moisture in skin and joints, promoting hydration and flexibility.

48. Reishi Mushroom – Immune-modulating mushroom that improves sleep, reduces anxiety, and supports adrenal health.

49. Astragalus Root – Enhances immune response and helps reduce fatigue while supporting hormone balance.

50. Quercetin – Flavonoid that reduces inflammation, supports respiratory health, and may stabilize histamine levels.

51. N-Acetyl Cysteine (NAC) – Precursor to glutathione; supports detoxification, lung health, and mental clarity.

52. Kelp – Natural source of iodine that supports thyroid function and helps regulate metabolism.

53. DIM (Diindolylmethane) – Supports estrogen metabolism and helps maintain healthy hormone balance.

54. Inositol – Supports neurotransmitter signaling and may help with mood swings and anxiety.

55. Glutathione – The body’s master antioxidant; protects cells from oxidative stress and supports liver detox.

56. PQQ (Pyrroloquinoline Quinone) – Supports mitochondrial health and brain function, especially important as cognitive function can decline during menopause.

57. Lecithin – Supports brain function, liver health, and may help manage hot flashes.

58. Saffron Extract – Shown to improve mood, reduce anxiety, and support overall emotional well-being.

59. Holy Basil (Tulsi) – Adaptogen that helps manage stress, improve mood, and regulate cortisol levels.

60. DHEA (Dehydroepiandrosterone) – A hormone precursor that can support libido, bone density, and energy (should be used under medical supervision).

61. Omega-7 (Palmitoleic Acid) – Supports skin and mucous membrane hydration, including vaginal dryness.

62. Vitamin A – Supports skin health, vision, and immune function. Works synergistically with other antioxidants.

63. Copper – Helps form red blood cells, supports brain and heart health, and balances zinc levels.

64. Manganese – Involved in bone formation, metabolism, and antioxidant function.

65. Lecithin – Aids in fat metabolism and supports brain and liver health.


Conclusion Menopause is a unique journey for every woman, but incorporating the right vitamins and supplements can help ease the transition and enhance overall quality of life. Be sure to consult with a healthcare provider to determine which supplements are appropriate for your personal health profile.

Stay informed. Stay empowered. Menopause matters.

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